Effect of natural Dead Sea Minerals on Hormone Modulation and Body Weight Reduction in Women: Review and Analysis of Observational Data.
Abstract
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Objective: To evaluate the effects of a nighttime mineral supplementation protocol inspired by the composition of the Dead Sea on weight loss and metabolic parameters in overweight women.
Methods: Narrative review and analysis of observational data from users of a mineral protocol (magnesium, potassium, and trace elements), focusing on appetite, body weight, abdominal circumference, and markers of inflammation. The product’s trade name has been suppressed.
Results: Case reports and series indicated an average weight loss of 8.5–14.2 kg in 30–90 days, a 15–25% reduction in abdominal circumference, and improved sleep/energy. No serious adverse events were observed.
Conclusion: The nighttime mineral supplementation protocol has been shown to be a safe, noninvasive, and adjuvant strategy for weight control. Randomized clinical trials are recommended.
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Key points
- Non-pharmacological approach focused on endogenous GLP-1/GIP.
- Facilitates adherence in the maternal context (low time available).
- Favorable safety profile in observational data.
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Introduction
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Excess weight is prevalent and multifactorial, influenced by hormonal, inflammatory, and behavioral changes. Insufficient weight recovery is associated with maternal cardiometabolic risk in the medium term. Effective and safe interventions with high adherence are a priority in this context.
GLP-1 analogs are effective, but costs and adverse effects limit their widespread use. Thus, interest in natural alternatives capable of modulating endogenous incretin production (GLP-1/GIP) and reducing inflammation in adipocytes is growing.
Methods
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A narrative review combined with descriptive analysis of case series of users of a nocturnal mineral protocol (magnesium, potassium and trace elements) was carried out, with daily oral intake before sleep, for 30–90 days.
- Population: Overweight women without serious active comorbidities.
- Outcomes: weight variation; abdominal circumference; self-reports of appetite, mood and sleep; adverse events.
- Analysis: qualitative synthesis and descriptive statistics of observational records; there was no pharmacological intervention.
Note: Commercial data and product brand have been suppressed; this text presents observational evidence and does not replace randomized clinical trials.
Results
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- Weight loss: average 8.5–14.2 kg in 30–90 days, with response associated with adherence and baseline BMI.
- Abdominal circumference: average reduction of 15–25% in 8–12 weeks.
- Appetite and energy: subjective decrease in nighttime hunger and improvement in mood/sleep in < 2 weeks.
- Safety: absence of serious events; mild and transient complaints of gastrointestinal discomfort in a minority of cases.
The findings suggest multifactorial improvement compatible with incretin modulation and reduction of inflammation in adipocytes, favoring fat mobilization.
Discussion
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The mechanistic hypothesis involves: (i) magnesium support for glucose metabolism and autonomic nervous system tone; (ii) potassium’s role in electrolyte homeostasis and possible indirect influence on inflammation; and (iii) trace elements as metabolic cofactors. Together, these elements may promote endogenous GLP-1/GIP production and improve energy balance.
Compared to restrictive strategies, the simplicity of the nighttime protocol increases adherence in the postpartum period as well. However, controlled studies are needed to estimate the magnitude of the effect, the dose-response relationship, and subgroups.
Limitations: observational design; selection and reporting biases; lack of active/placebo control; heterogeneity in postpartum time and dietary routines.
Conclusion
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The nighttime mineral protocol, inspired by the composition of the Dead Sea, has a favorable safety profile and potential usefulness as an adjunct to weight loss. Randomized clinical trials are recommended to confirm efficacy and establish guidelines.
References
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- Drucker DJ. Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell Metab. 2018;27(4):740–756.
- Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199–8226.
- Barbagallo M, Dominguez LJ. Magnesium and Aging. Curr Pharm Des. 2010;16(7):832–839.
- Ben Assayag E, et al. Health benefits of the Dead Sea minerals: an evidence-based review. Isr Med Assoc J. 2019;21(3):188–194.
- Hellerstein MK. Gluconeogenesis and Energy Metabolism in Human Pregnancy. Endocrinol Metab Clin North Am. 2006;35(2):277–292.
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